Synthetic Genomes for Synthetic Biology
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Microfluidic oligonucleotide synthesizer
a microfluidic platform for parallel solid phase synthesis of oligonucleotides that can greatly reduce the cost of gene synthesis by reducing reagent consumption (by 100-fold) while maintaining a100 pmol synthesis scale so there is no need for amplification before assembly
Grand challenges for engineering and Synthetic Biology
In a new field called “synthetic biology,” novel biomaterials are being engineered to replace or aid in the repair of damaged body tissues. Some are scaffolds that contain biological signals that attract stem cells and guide their growth into specific tissue types. Mastery of synthetic tissue engineering could make it possible to regenerate tissues and organs.
Fusion between synthetic vesicles
The spontaneous fusion between cationic vesicles and fatty acid vesicles has been revealed by assessing the mixing of their aqueous contents. Vesicle fusion can provide an useful “origin of life” model.
Gently down the stream
A microfluidic technique uses a continuous fluid stream to generate monodisperse unilamellar phospholipid vesicles from a single bilayer (see picture). Since the vesicles are robust and efficiently encapsulate high concentrations of various molecules, they are useful as delivery vehicles and as model cellular systems.
